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Multiple myeloma: PharmaMar starts a quadruple combination study with plitidepsina (Aplidin*)

PharmaMar announced the start of a multicenter quadruple combination clinical study with Aplidin* (plitidepsina), along with other compounds for the treatment of multiple myeloma. The main objective of this study is to evaluate the recommended dose (RD), the efficacy of the combination along with the safety profile, evaluating potential response and resistance markers, amongst other parameters.

The above mentioned study will follow the same line in combating multiple myeloma with compounds that have different mechanisms of action to increase the success rate. Aplidin* has already demonstrated, through other studies, its potential in combining with other compounds, due to its lack of hematological toxicity. Given this, Aplidin* can be administered at a maximum dose, with the corresponding increase in efficacy of the therapy. This will put Aplidin* on the first line of multiple myeloma treatment. In this quadruple combination; Aplidin* will be administered along with pomalidomide, bortezomib and dexamethasone, products, all of which are indicated in early stages of treatment.

Various centers, both in Spain and in the Czech Republic are taking part. As Dr Arturo Soto, director of the Clinical Department at PharmaMar Business Unit explains, “Aplidin* is an ideal compound for combining with other drugs that are commonly used in the treatment of multiple myeloma, given the absence of hematological toxicity, its excellent safety profile and good tolerability. With this molecule we can provide the actual therapeutic arsenal with a different mechanism of action to attack myeloma cells. In the future, the treatment of multiple myeloma patients will be based on combined therapies”.

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